Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model. Issue 7 (17th February 2016)

• Record Type: Journal Article
• Authors: Pereira, Talita Carneiro Brandão; Campos, Maria Martha; Bogo, Maurício Reis
• Is Part Of: Journal of applied toxicology. Volume 36:Issue 7(2016)
• Page Start: 876
• Page End: 885
• Publication Date: 2016-02-17
• Subjects: copper -- oxidative stress -- inflammation -- zebrafish -- ChIn assay -- copper‐induced inflammation; Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.3303
• Languages: English
• ISSNs: 0260-437X

Abstract

Abstract: Copper is an essential micronutrient and a key catalytic cofactor in a wide range of enzymes. As a trace element, copper levels are tightly regulated and both its deficit and excess are deleterious to the organism. Under inflammatory conditions, serum copper levels are increased and trigger oxidative stress responses that activate inflammatory responses. Interestingly, copper dyshomeostasis, oxidative stress and inflammation are commonly present in several chronic diseases. Copper exposure can be easily modeled in zebrafish; a consolidated model in toxicology with increasing interest in immunity‐related research. As a result of developmental, economical and genetic advantages, this freshwater teleost is uniquely suitable for chemical and genetic large‐scale screenings, representing a powerful experimental tool for a whole‐organism approach, mechanistic studies, disease modeling and beyond. Copper toxicological and more recently pro‐inflammatory effects have been investigated in both larval and adult zebrafish with breakthrough findings. Here, we provide an overview of copper metabolism in health and disease and its effects on oxidative stress and inflammation responses in zebrafish models. Copper‐induced inflammation is highlighted owing to its potential to easily mimic pro‐oxidative and pro‐inflammatory features that combined with zebrafish genetic tractability could help further in the understanding of copper metabolism, inflammatory responses and related diseases. Copyright © 2016 John Wiley & Sons, Ltd. Abstract : Copper is an essential micronutrient but also, potentially toxic and in excess, triggers oxidative stress responses that activate inflammation. Copper exposure can be easily modeled in zebrafish; a consolidated model in toxicology with increasing interest in immunity‐related research. Copper toxicological and more recently pro‐inflammatory effects have been investigated in both larval and adult zebrafish with breakthrough findings. Here, we provide an overview of copper metabolism in health and disease and its effects on oxidative stress and inflammation responses in zebrafish models.