The Effects of the Organic Flame‐Retardant 1, 2‐Dibromo‐4‐(1, 2‐dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines. Issue 5 (5th January 2016)

• Record Type: Journal Article
• Authors: Wong, Lilian I. L.; Reers, Alexandra R.; Currier, Heidi A.; Williams, Tony D.; Cox, Michael E.; Elliott, John E.; Beischlag, Timothy V.
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 30:Issue 5(2016:May)
• Page Start: 239
• Page End: 242
• Publication Date: 2016-01-05
• Subjects: Organic Flame Retardant -- Endocrine Disruptor -- Androgen Receptor -- LNCaP; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.21784
• Languages: English
• ISSNs: 1095-6670

Abstract

ABSTRACT: The effects of the organic flame retardant 1, 2‐Dibromo‐4‐(1, 2‐dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ‐/δ‐TBECH alone led to a significant increase in prostate‐specific antigen (PSA) mRNA accumulation, both the α‐/‐TBECH and γ‐/δ‐TBECH mixtures repressed androgen‐inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor.