A General and Selective Rhodium‐Catalyzed Reduction of Amides, N‐Acyl Amino Esters, and Dipeptides Using Phenylsilane. Issue 21 (13th April 2016)

• Record Type: Journal Article
• Authors: Das, Shoubhik; Li, Yuehui; Lu, Liang‐Qiu; Junge, Kathrin; Beller, Matthias
• Is Part Of: Chemistry. Volume 22:Issue 21(2016)
• Page Start: 7050
• Page End: 7053
• Publication Date: 2016-04-13
• Subjects: amides -- esters -- hydrosilylation -- peptides -- rhodium; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201600535
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: This article describes a selective reduction of functionalized amides, including N ‐acyl amino esters and dipeptides, to the corresponding amines using simple [Rh(acac)(cod)]. The catalyst shows excellent chemoselectivity in the presence of different sensitive functional moieties. Abstract : A selective reduction of functionalized amides, including N ‐acyl amino esters and dipeptides, to the corresponding amines using simple [Rh(acac)(cod)] is described (see scheme). The catalyst shows excellent chemoselectivity in the presence of different sensitive functional moieties. Even the selective reduction of a secondary amide bond in the presence of a ketone is possible.