Identification and Biological Activities of Long‐Chain Peptaibols Produced by a Marine‐Derived Strain of Trichoderma longibrachiatum. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Mohamed‐Benkada, Mustapha; François Pouchus, Yves; Vérité, Philippe; Pagniez, Fabrice; Caroff, Nathalie; Ruiz, Nicolas
• Is Part Of: Chemistry & biodiversity. Volume 13:Issue 5(2016:May)
• Page Start: 521
• Page End: 530
• Publication Date: 2016-05
• Subjects: Long‐chain peptaibols -- Marine‐derived fungi -- Trichoderma longibrachiatum -- Longibrachins A‐0, A‐II‐a, and A‐IV‐b; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201500159
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : Six long‐chain peptaibols, 1 – 6, were identified from agar cultures of a marine‐derived Trichoderma longibrachiatum Rifai strain (MMS151) isolated from blue mussels. The structure elucidation was carried out using electrospray ionization ion trap mass spectrometry (ESI‐IT‐MS) and GC/EI‐MS. The long‐chain peptaibols exhibited the general building scheme Ac‐Aib‐Ala‐Aib‐Ala‐Aib‐ XXX ‐Gln‐Aib‐Vxx‐Aib‐Gly‐ XXX ‐Aib‐Pro‐Vxx‐Aib‐ XXX ‐Gln‐Gln‐Pheol and were similar or identical to recurrent 20‐residue peptaibols produced by Trichoderma spp. Three new sequences were identified and were called longibrachins A‐0, A‐II‐a, and A‐IV‐b. The isolated peptaibols were assayed for cytotoxic, antibacterial, and antifungal activities, and acute toxicity on Dipteran larvae. Abstract :