Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions. Issue 5 (23rd April 2016)

• Record Type: Journal Article
• Authors: Tian, Li; Luo, Yong‐Chun; Hu, Xiu‐Qin; Xu, Peng‐Fei
• Is Part Of: Asian journal of organic chemistry. Volume 5:Issue 5(2016)
• Page Start: 580
• Page End: 607
• Publication Date: 2016-04-23
• Subjects: aminocatalysis -- catalytic cascade reactions -- hydrogen-bonding catalysis -- ion-pairing catalysis -- quaternary centers; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201500486
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: Quaternary carbon stereocenters are present in a wide variety of organic compounds and drug molecules. Highly enantioselective construction of such quaternary carbon stereocenters has received considerable attention owing to the great challenges in their syntheses. With the development of asymmetric organocatalytic cascade reactions, several efficient methods for the construction of optically pure compounds with quaternary carbon centers have been developed. This focused review highlights the asymmetric synthesis of chiral compounds with quaternary centers through organocatalytic cascade reactions. Abstract : Cascades of quaternary centers : Quaternary carbon stereocenters are present in a wide variety of organic compounds and drug molecules. Construction of such stereocenters is challenging. This focused review highlights the synthesis methods of chiral compounds with quaternary centers by organocatalytic cascade reactions.