(Pentamethylcyclopentadienyl)cobalt(III)‐Catalyzed Oxidative [4+2] Annulation of NH Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines. Issue 10 (15th April 2016)

• Record Type: Journal Article
• Authors: Zhang, Shang‐Shi; Liu, Xu‐Ge; Chen, Shi‐Yong; Tan, Dong‐Hang; Jiang, Chun‐Yong; Wu, Jia‐Qiang; Li, Qingjiang; Wang, Honggen
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 10(2016)
• Page Start: 1705
• Page End: 1710
• Publication Date: 2016-04-15
• Subjects: annulation -- cerium salts -- CH activation -- cobalt -- isoquinolines; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600025
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A synthetic method for isoquinoline synthesis via a [4+2] annulation of NH imines with alkynes using the high‐valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described. Cerium(IV) sulfate was found to be an efficient oxidant in lieu of the commonly used copper or silver salts. Broad substrate scope, high functional group tolerance, and generally good yields were observed. Abstract :