Metal‐Organic‐Framework‐Coated Optical Fibers as Light‐Triggered Drug Delivery Vehicles. (8th March 2016)

• Record Type: Journal Article
• Authors: Nazari, Marziyeh; Rubio‐Martinez, Marta; Tobias, Gerard; Barrio, Jorge Pérez; Babarao, Ravichandar; Nazari, Fatemeh; Konstas, Kristina; Muir, Benjamin W.; Collins, Stephen F.; Hill, Anita J.; Duke, Mikel C.; Hill, Matthew R.
• Is Part Of: Advanced functional materials. Volume 26:Number 19(2016)
• Page Start: 3244
• Page End: 3249
• Publication Date: 2016-03-08
• Subjects: 5‐fluorouracil -- metal‐organic frameworks -- optical fiber -- triggered release -- UiO‐66; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201505260
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Physical delivery of anticancer drugs in controlled anatomic locations can complement the advances being made in chemo‐selective therapies. To this end, an optical fiber catheter is coated in a thin layer of metal organic framework UiO‐66 and the anticancer drug 5‐Fluorouracil (5‐FU) is deposited within the pores. Delivery of light of appropriate wavelength through the fiber catheter is found to trigger the release of 5‐FU on demand, offering a new route to localized drug administration. The system exhibits great potential with as much as 110 × 10 −6 m of 5‐FU delivered within 1 min from one fiber. Abstract : Encapsulation and controlled release of 5‐Fluorouracil from the UiO‐66 thin film optical fiber is reported. The active drug is released upon switching on the light at the other end of the optical fiber, making it a convenient method to deliver toxic drugs into remote areas of human body.