Development of an AIDS vaccine using Sendai virus vectors. Issue 45 (9th November 2015)

• Record Type: Journal Article
• Authors: Ishii, Hiroshi; Matano, Tetsuro
• Is Part Of: Vaccine. Volume 33:Issue 45(2015)
• Page Start: 6061
• Page End: 6065
• Publication Date: 2015-11-09
• Subjects: AIDS vaccine -- Sendai virus vector -- HIV -- SIV; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.06.114
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.