High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Kristensen, Louise; Kristensen, Thomas; Abildgaard, Niels; Thomassen, Mads; Frederiksen, Mikael; Mourits-Andersen, Torben; Møller, Michael Boe
• Is Part Of: Leukemia research. Volume 39:Issue 6(2015:Jun.)
• Page Start: 555
• Page End: 560
• Publication Date: 2015-06
• Subjects: Chronic lymphocytic leukemia -- Autophagy -- BECN1 -- PIK3C3 -- PIK3R4 -- Prognosis; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.02.008
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: The PI3K core complex is central to initiation of autophagy. Expression of PI3K core complex genes are examined in CLL. High mRNA expression of these genes is associated with poor outcome. The PI3K core complex might be important in CLL pathobiology. Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in the Western world. Autophagy is a highly conserved process in eukaryotic cells. In CLL autophagy is involved in mediating the effect of chemotherapy but the role of autophagy in CLL pathogenesis remains unknown. In the present study, we used real-time RT-PCR to analyze expression of the PIK3C3, PIK3R4, and BECN1 genes. These genes encode the components of the PI3K core complex, which is central to initiation of autophagy. A consecutive series of 149 well-characterized CLL cases from Region of Southern Denmark were included in the study. All three genes were observed to be independent markers of prognosis in CLL with high expression being associated with more aggressive disease. With this clear association with outcome in CLL, these genes thereby represent promising candidates for future functional studies on the role of autophagy in CLL, and they may further represent targets of treatment.