IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Zeng, Li; Perks, Claire M.; Holly, Jeff M.P.
• Is Part Of: Growth hormone & IGF research. Volume 25:Issue 3(2015:Jun.)
• Page Start: 103
• Page End: 107
• Publication Date: 2015-06
• Subjects: IGFBP-2 -- PTEN -- PI3K -- IGF-II -- Feedback; Growth regulators -- Periodicals; Growth -- Regulation -- Periodicals; Somatomedin -- Periodicals; Somatomedins -- Periodicals; Growth Hormone -- Periodicals; Growth Substances -- Periodicals; Croissance -- Régulation -- Périodiques; Croissance -- Régulateurs -- Périodiques; Somatotrophine -- Périodiques; Somatomédine -- Périodiques; Growth -- Regulation; Growth regulators; Electronic journals; Periodicals; Electronic journals; 612.4
• DOI: 10.1016/j.ghir.2015.01.003
• Languages: English
• ISSNs: 1096-6374

Abstract

Abstract: IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'. Highlights: IGFBP-2 is the second most abundant of the IGFBPs in the circulation. IGFBP2 levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state. PTEN is the second most commonly mutated gene in a variety of common cancers. Recent evidence indicates that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the evidence that these extracellular and intracellular modulators of the IGF-system are linked.