Neoadjuvant and adjuvant chemotherapy combined with anatomical resection of feline injection‐site sarcoma: results in 21 cats. (7th February 2014)

• Record Type: Journal Article
• Authors: Bray, J.; Polton, G.
• Is Part Of: Veterinary and comparative oncology. Volume 14:Number 2(2016:Jun.)
• Page Start: 147
• Page End: 160
• Publication Date: 2014-02-07
• Subjects: injection site -- neoadjuvant -- sarcoma -- surgery; Veterinary oncology -- Periodicals; Neoplasms -- veterinary -- Periodicals; 636.0896994005
• DOI: 10.1111/vco.12083
• Languages: English
• ISSNs: 1476-5810

Abstract

Abstract: This study assesses the outcome of two combined treatment strategies for the treatment of feline injection‐site sarcoma (FISS). Twenty‐one cats with primary or recurrent FISS received 3 cycles of neoadjuvant chemotherapy with epirubicin (25 mg m −2 ), then an anatomical resection of the entire muscle compartment containing the tumour was performed based on the findings of co‐axial imaging. Cats then received a further 3 cycles of adjuvant chemotherapy. Follow‐up was performed by telephone contact with a median follow‐up time of 1072 days. Three cats (14%) developed local tumour recurrence at days 264, 664 and 1573 after surgery. A median survival time could not be calculated as over 80% of the study population remained alive or were censored due to death from other causes. When compared to historical controls, the results of this study demonstrate superior rates of tumour‐free survival and disease‐free interval.