Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction. Issue 3 (13th October 2015)

• Record Type: Journal Article
• Authors: Han, Sang Won; Song, Tae Jin; Bushnell, Cheryl D.; Lee, Sung‐Soo; Kim, Seo Hyun; Lee, Jun Hong; Kim, Gyu Sik; Kim, Ok‐Joon; Koh, Im‐Seok; Lee, Jong Yun; Suk, Seung‐Han; Lee, Sung Ik; Nam, Hyo Suk; Lee, Kyung‐Yul; Park, Jae Hyeon
• Is Part Of: Journal of neuroimaging. Volume 26:Issue 3(2016)
• Page Start: 351
• Page End: 354
• Publication Date: 2015-10-13
• Subjects: Lacunar infarcts -- uric acid -- white matter hyperintensities; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12308
• Languages: English
• ISSNs: 1051-2284

Abstract

ABSTRACT: BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double‐blind, placebo‐controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2‐weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm 3 (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age ( P < .001) and serum UA ( P = .013) were significantly associated with WMH volume. Age‐adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction ( r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.