Tissue Doppler imaging in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome before and after fetal aortic valvuloplasty. (17th April 2016)

• Record Type: Journal Article
• Authors: Wohlmuth, C.; Wertaschnigg, D.; Wieser, I.; Arzt, W.; Tulzer, G.
• Is Part Of: Ultrasound in obstetrics & gynecology. Volume 47:Number 5(2016)
• Page Start: 608
• Page End: 615
• Publication Date: 2016-04-17
• Subjects: critical aortic stenosis -- fetal cardiac intervention -- fetal surgery -- hypoplastic left heart syndrome -- intrauterine valvuloplasty -- tissue Doppler imaging; Ultrasonics in obstetrics -- Periodicals; Generative organs, Female -- Diseases -- Diagnosis -- Periodicals; Diagnosis, Ultrasonic -- Periodicals; Genital Diseases, Female -- ultrasonography -- Periodicals; Ultrasonography, Prenatal -- Periodicals; 618.047543
• DOI: 10.1002/uog.14885
• Languages: English
• ISSNs: 0960-7692

Abstract

ABSTRACT: Objectives: Fetal aortic valvuloplasty can improve filling and reduce afterload of the left ventricle in critical aortic stenosis. Success of an intrauterine intervention is currently measured by technical success, clinical survival and eventual postnatal biventricular physiology. In the present study we investigated the use of tissue Doppler imaging (TDI) to evaluate changes in ventricular function assessed before and after prenatal aortic valvuloplasty. Methods: Between October 2008 and December 2012, cardiac function was assessed by TDI before and after intervention in 23 fetuses that underwent technically successful valvuloplasty for critical aortic stenosis and in which postnatal outcome was known. The measurements were transformed into gestational age‐independent Z‐ scores where appropriate. Results: Mean ± SD gestational age at intervention was 27.5 ± 3.1 weeks. Of the 23 fetuses, 14 had biventricular outcome. Before intervention all left ventricular (LV) TDI‐derived parameters and mitral annular plane systolic excursion (MAPSE) were severely abnormal. It was possible to demonstrate considerably improved cardiac function after technically successful valvuloplasty. Among fetuses with postnatal biventricular outcome, TDI‐derived LV myocardial peak velocity during early diastole (E′) and myocardial peak velocity during systole in the ejection phase (S′) significantly increased, E′/myocardial peak velocity during late diastole with atrial contraction (A′) increased towards normal values, and LV transmitral‐to‐mitral‐annular diastolic velocity ratio (E/E′) and myocardial performance index (MPI′) decreased but remained abnormally elevated. In addition, right ventricular A′, S′ and MPI′ significantly improved after intervention. Conclusion: Technically successful fetal aortic valvuloplasty led to significantly improved myocardial performance. It was possible to use TDI to detect distinct changes in ventricular function and TDI‐derived parameters correlated with a biventricular outcome after birth. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.