Fluorescent genipin cross-linked REDV-conjugated polymeric microbubbles for human vascular endothelial cell (HVEC) targeting. Issue 39 (4th April 2016)

• Record Type: Journal Article
• Authors: Liu, Zhe; Shi, Changcan; Li, Yihong; Song, Yuanhui; Xu, Qien
• Is Part Of: RSC advances. Volume 6:Issue 39(2016)
• Page Start: 32710
• Page End: 32714
• Publication Date: 2016-04-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra00992a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Fluorescent polymeric microbubbles conjugated with REDV peptides were fabricated to achieve HVECs active targeting. The degradation, cytotoxicity and targeting features endowed them potential candidates in early molecular diagnosis for cardiovascular diseases. Abstract : Polymeric microbubbles modified with chitosan and genipin were fabricated via emulsification, electrostatic interaction and cross-linking to afford intrinsic fluorescence. REDV peptides were conjugated to achieve HVEC active targeting. The degradation, cytotoxicity and targeting features made them potential candidates in early molecular diagnosis for cardiovascular diseases.