A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity. Issue 46 (20th April 2016)
- Record Type:
- Journal Article
- Title:
- A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity. Issue 46 (20th April 2016)
- Main Title:
- A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity
- Authors:
- Cuccioloni, M.
Bonfili, L.
Mozzicafreddo, M.
Cecarini, V.
Pettinari, R.
Condello, F.
Pettinari, C.
Marchetti, F.
Angeletti, M.
Eleuteri, A. M. - Abstract:
- Abstract : A ruthenium(ii ) p -cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Abstract : A ruthenium(ii ) p -cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.
- Is Part Of:
- RSC advances. Volume 6:Issue 46(2016)
- Journal:
- RSC advances
- Issue:
- Volume 6:Issue 46(2016)
- Issue Display:
- Volume 6, Issue 46 (2016)
- Year:
- 2016
- Volume:
- 6
- Issue:
- 46
- Issue Sort Value:
- 2016-0006-0046-0000
- Page Start:
- 39636
- Page End:
- 39641
- Publication Date:
- 2016-04-20
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6ra06403e ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2378.xml