Design of thermoresponsive polymeric gates with opposite controlled release behaviors. Issue 48 (29th April 2016)

• Record Type: Journal Article
• Authors: Guisasola, Eduardo; Baeza, Alejandro; Talelli, Marina; Arcos, Daniel; Vallet-Regí, María
• Is Part Of: RSC advances. Volume 6:Issue 48(2016)
• Page Start: 42510
• Page End: 42516
• Publication Date: 2016-04-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra02260j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Magnetic-responsive mesoporous silica nanoparticles were coated with an engineered thermoresponsive co-polymer. The release profile can be tuned by a different grafting density and structure of the polymer with the same transition temperature (42 °C). Abstract : Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores are used as heating sources when they are exposed to an alternating magnetic field. The polymer structure suffers a change from hydrophilic to hydrophobic state when the temperature is raised above the lower critical solution temperature (LCST) or volume phase transition temperature (VPTT), acting as a gate-keeper of a model drug trapped inside the silica matrix. Fluorescein departure can be tuned employing two different polymer structures on the silica surface which exhibit the same transition temperature (42 °C) but a different grafting density: one of them being a dense crosslinked polymer network and the other one a hairy linear polymer layer. The release profile reveals to be the opposite between these two different coatings, allowing suitable drug release behavior for different clinical situations.