Synthesis of polysarcosine from air and moisture stable N-phenoxycarbonyl-N-methylglycine assisted by tertiary amine base. Issue 18 (14th April 2016)

• Record Type: Journal Article
• Authors: Doriti, Afroditi; Brosnan, Sarah M.; Weidner, Steffen M.; Schlaad, Helmut
• Is Part Of: Polymer chemistry. Volume 7:Issue 18(2016)
• Page Start: 3067
• Page End: 3070
• Publication Date: 2016-04-14
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c6py00221h
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : Well-defined polysarcosines are synthesized from a stable urethane derivative of N -methylglycine, avoiding the direct use of NCA. Abstract : Polysarcosine ( M n = 3650–20 000 g mol −1, Đ ∼ 1.1) was synthesized from the air and moisture stable N -phenoxycarbonyl- N -methylglycine. Polymerization was achieved by in situ transformation of the urethane precursor into the corresponding N -methylglycine- N -carboxyanhydride, when in the presence of a non-nucleophilic tertiary amine base and a primary amine initiator.