A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli. Issue 15 (24th March 2016)

• Record Type: Journal Article
• Authors: Yan, Xibo; Sivignon, Adeline; Barnich, Nicolas; Gouin, Sébastien G.; Bouckaert, Julie; Fleury, Etienne; Bernard, Julien
• Is Part Of: Polymer chemistry. Volume 7:Issue 15(2016)
• Page Start: 2674
• Page End: 2683
• Publication Date: 2016-03-24
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c6py00118a
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : Heptyl Mannose-functionalized copolymers are efficient anti-adhesives of type 1 Piliated E. coli . Abstract : A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT (co)polymerizations of glycidyl methacrylate (GMA) and N -[7-(α-d -mannopyranosyloxy)heptyl] methacrylamide (HMM) and (ii) epoxy-amine post-modifications with ethanolamine, (2-aminoethyl)trimethylammonium chloride or taurine. Examination of the anti-adhesive properties against type 1 piliated E. coli allowed for identifying copolymers among the three series of post-modified glycopolymers capable of efficiently inhibiting bacterial adhesion at 0.1 and 1 μM (on a mannose unit basis) in pre and post-incubation adhesion assays respectively.