Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies. Issue 15 (23rd March 2016)

• Record Type: Journal Article
• Authors: Murray, Alexander T.; Challinor, Jonathan D.; Gulácsy, Christina E.; Lujan, Cristina; Hatcher, Lauren E.; Pudney, Christopher R.; Raithby, Paul R.; John, Matthew P.; Carbery, David R.
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 15(2016)
• Page Start: 3787
• Page End: 3792
• Publication Date: 2016-03-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00361c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The formation and chemistry of flavin–indole charge transfer (CT) complexes has been studied using a model cationic flavin. Abstract : The formation and chemistry of flavin–indole charge transfer (CT) complexes has been studied using a model cationic flavin. The ability to form a CT complex is sensitive to indole structure as gauged by spectroscopic, kinetics and crystallographic studies. Single crystals of sufficient quality of a flavin–indole CT complex, suitable for X-ray diffraction, have been grown, allowing solid-state structural analysis. When CT complex formation is conducted in d4 -methanol, an efficient and synthetically useful C -3 indole deuteration is observed.