Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications. Issue 13 (10th March 2016)

• Record Type: Journal Article
• Authors: Jäger, Eliézer; Höcherl, Anita; Janoušková, Olga; Jäger, Alessandro; Hrubý, Martin; Konefał, Rafał; Netopilik, Miloš; Pánek, Jiří; Šlouf, Miroslav; Ulbrich, Karel; Štěpánek, Petr
• Is Part Of: Nanoscale. Volume 8:Issue 13(2016)
• Page Start: 6958
• Page End: 6963
• Publication Date: 2016-03-10
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nr00791k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Fluorescente boronate-based polymer nanoparticles specifically release their drug cargo under concentrations of reactive oxygen species (ROS) that are commonly found in the intracellular environment of certain tumors and of inflamed tissues. Abstract : A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.