Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity. Issue 38 (21st April 2016)

• Record Type: Journal Article
• Authors: Zhou, Hangyu; Wang, Guangchuan; Li, Xiao-Feng; Li, Yaling; Zhu, Shun-Ya; Qin, Cheng-Feng; Tang, Ruikang
• Is Part Of: Chemical communications. Volume 52:Issue 38(2016)
• Page Start: 6447
• Page End: 6450
• Publication Date: 2016-04-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc02595a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Encapsulation of vaccines within alumina, a FDA approved inorganic adjuvant, can produce a more robust vaccine formulation with improved thermostability and enhanced immunogenicity. Abstract : Developing vaccine formulations with excellent thermostability and immunogenicity remains a great challenge. By in situ encapsulating a live-attenuated strain of human enterovirus 71 (EV71) in alumina, we obtained a robust vaccine formulation named EV71@NanoAlum, which features significantly enhanced thermostability and immunogenicity. This attempt follows a material-based tactic for vaccine improvement.