Biosensing made easy with PEG-targeted bi-specific antibodies. Issue 33 (5th April 2016)

• Record Type: Journal Article
• Authors: Raftery, Lyndon J.; Grewal, Yadveer S.; Howard, Christopher B.; Jones, Martina L.; Shiddiky, Muhammad J. A.; Carrascosa, Laura G.; Thurecht, Kristofer J.; Mahler, Stephen M.; Trau, Matt
• Is Part Of: Chemical communications. Volume 52:Issue 33(2016)
• Page Start: 5730
• Page End: 5733
• Publication Date: 2016-04-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01916a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Abstract : Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.