Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics. Issue 31 (24th March 2016)

• Record Type: Journal Article
• Authors: Burslem, George M.; Kyle, Hannah F.; Breeze, Alexander L.; Edwards, Thomas A.; Nelson, Adam; Warriner, Stuart L.; Wilson, Andrew J.
• Is Part Of: Chemical communications. Volume 52:Issue 31(2016)
• Page Start: 5421
• Page End: 5424
• Publication Date: 2016-03-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc01812b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An extended sequence of α-amino acids in HIF-1α is replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide to reproduce its p300 recognition properties. Abstract : Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.