Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells. Issue 29 (21st March 2016) - Shi, Qiuyan
Abstract : The first 19 F MRI sensitive theranostic agent was discovered through site-specific modification of salinomycin and click library derivatization. Abstract : Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and 19 F MRI sensitivity was discovered as a novel theranostic agent.