Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides. Issue 27 (14th March 2016)
- Record Type:
- Journal Article
- Title:
- Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides. Issue 27 (14th March 2016)
- Main Title:
- Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides
- Authors:
- Ueberschaar, Nico
Meyer, Florian
Dahse, Hans-Martin
Hertweck, Christian - Abstract:
- Abstract : 1, 4′-Bipiperidine-1′-carbamate residues were evaluated as sugar surrogates in daunorubicin and chartreusin, yielding water-soluble derivatives and prodrugs with dramatically improved antiproliferative activities. Abstract : DNA-intercalating polyketide glycosides are important leads for cancer therapeutics, yet their use is often limited by their low solubility and challenging synthetic protocols. To overcome these limitations, we employed 1, 4′-bipiperidine-1′-carbamate residues as sugar surrogates in daunorubicin and chartreusin, yielding water-soluble derivatives and prodrugs with dramatically improved antiproliferative activities.
- Is Part Of:
- Chemical communications. Volume 52:Issue 27(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 27(2016)
- Issue Display:
- Volume 52, Issue 27 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 27
- Issue Sort Value:
- 2016-0052-0027-0000
- Page Start:
- 4894
- Page End:
- 4897
- Publication Date:
- 2016-03-14
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6cc00890a ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1912.xml