Structure-guided stereoselectivity inversion of a short-chain dehydrogenase/reductase towards halogenated acetophenones. Issue 37 (18th April 2016)
- Record Type:
- Journal Article
- Title:
- Structure-guided stereoselectivity inversion of a short-chain dehydrogenase/reductase towards halogenated acetophenones. Issue 37 (18th April 2016)
- Main Title:
- Structure-guided stereoselectivity inversion of a short-chain dehydrogenase/reductase towards halogenated acetophenones
- Authors:
- Li, Aipeng
Ye, Lidan
Yang, Xiaohong
Yang, Chengcheng
Gu, Jiali
Yu, Hongwei - Abstract:
- Abstract : The structure-guided rational design of an NADH-dependent short-chain dehydrogenase/reductase (SDR) reversed the stereoselectivity towards halogenated acetophenones from Prelog to anti-Prelog. Abstract : The structure-guided rational design of an NADH-dependent short-chain dehydrogenase/reductase (SDR) reversed the stereoselectivity towards halogenated acetophenones from Prelog to anti-Prelog. The enzyme–substrate interactions involving an aromatic ring and a halogen atom were proven to play critical roles in determining the stereoselectivity of these ketone reductions besides the steric repulsion.
- Is Part Of:
- Chemical communications. Volume 52:Issue 37(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 37(2016)
- Issue Display:
- Volume 52, Issue 37 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 37
- Issue Sort Value:
- 2016-0052-0037-0000
- Page Start:
- 6284
- Page End:
- 6287
- Publication Date:
- 2016-04-18
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6cc00051g ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1368.xml