An efficient synthesis of 2-thio-5-amino substituted benzoquinones via KI catalyzed cascade oxidation/Michael addition/oxidation starting from hydroquinone. Issue 14 (27th January 2016)

• Record Type: Journal Article
• Authors: Lu, Yihuan; Zhao, Yuqiong; Wang, Shucheng; Wang, Xin; Ge, Zemei; Li, Runtao
• Is Part Of: RSC advances. Volume 6:Issue 14(2016)
• Page Start: 11378
• Page End: 11381
• Publication Date: 2016-01-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra26524j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient one-pot approach to 2-thio-5-amino substituted benzoquinones has been developed. The use of S-alkylisothiouronium salts as thiol equivalents is more convenient and environmental friendly. Abstract : A simple and efficient synthesis of 2-thio-5-amino substituted benzoquinones via KI catalyzed cascade oxidation/ S -Michael addition/oxidation/ N -Michael addition/oxidation starting from hydroquinone, amines and S -alkylisothiouronium salts was described. Various 2-thio-5-amino substituted benzoquinones were obtained by this method in moderate to good yields. The use of S -alkylisothiouronium salts as thiol equivalents is more convenient and environmental friendly.