Chimeric antigen receptor-redirected T cells return to the bench. Issue 1 (February 2016)

• Record Type: Journal Article
• Authors: Geldres, Claudia; Savoldo, Barbara; Dotti, Gianpietro
• Is Part Of: Seminars in immunology. Volume 28:Issue 1(2016)
• Page Start: 3
• Page End: 9
• Publication Date: 2016-02
• Subjects: Chimeric antigen receptor -- Adoptive immunotherapy; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2015.12.001
• Languages: English
• ISSNs: 1044-5323

Abstract

Highlights: Examination of key molecular attributes of CARs that influence functionality. Factors to consider in building a CAR. Coupling CARs with additional molecules to enhance their function. CAR-T toxicities. Abstract: While the clinical progress of chimeric antigen receptor T cell (CAR-T) immunotherapy has garnered attention to the field, our understanding of the biology of these chimeric molecules is still emerging. Our aim within this review is to bring to light the mechanistic understanding of these multi-modular receptors and how these individual components confer particular properties to CAR-Ts. In addition, we will discuss extrinsic factors that can be manipulated to influence CAR-T performance such as choice of cellular population, culturing conditions and additional modifications that enhance their activity particularly in solid tumors. Finally, we will also consider the emerging toxicity associated with CAR-Ts. By breaking apart the CAR and examining the role of each piece, we can build a better functioning cellular vehicle for optimized treatment of cancer patients.