Fluid phase recognition molecules in neutrophil-dependent immune responses. Issue 2 (April 2016)

• Record Type: Journal Article
• Authors: Jaillon, Sébastien; Ponzetta, Andrea; Magrini, Elena; Barajon, Isabella; Barbagallo, Marialuisa; Garlanda, Cecilia; Mantovani, Alberto
• Is Part Of: Seminars in immunology. Volume 28:Issue 2(2016)
• Page Start: 109
• Page End: 118
• Publication Date: 2016-04
• Subjects: ANCA anti-neutrophil cytoplasmic antibody -- C4BP C4b-binding protein -- CL collectin -- CRD C-terminal carbohydrate recognition domain -- CRP Creactive protein -- FHR-5 factor H-related protein 5 -- LPS lipopolysaccharide -- LTA lipotechoic acid -- MBL mannose-binding lectin -- MDA5 melanoma differentiation-associated gene 5 -- MPO myeloperoxidase -- NETs neutrophil extracellular traps -- NLR NOD-like receptors -- NOD nucleotide-binding oligomerization domain -- PAMP pathogen associated molecular patterns -- PGLYRP peptidoglycan recognition proteins -- PGRPs peptidoglycan recognition proteins -- PTX3 pentraxin 3 -- RIG-I retinoic acid-inducible gene I -- SAP serum amyloid P -- SP surfactant protein -- TLRs Toll like receptors; Neutrophil -- Pattern-recognition molecule -- Innate immunity -- Pentraxin -- Ficolin; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2016.03.005
• Languages: English
• ISSNs: 1044-5323

Abstract

Highlights: Soluble pattern recognition molecules belong to the humoral arm of innate immunity. Soluble pattern recognition molecules share effector mechanisms. Neutrophils are a reservoir of ready-made soluble pattern recognition molecules. Soluble pattern recognition molecules are involved in neutrophil effector functions. Abstract: The innate immune system comprises both a cellular and a humoral arm. Neutrophils are key effector cells of the immune and inflammatory responses and have emerged as a major source of humoral pattern recognition molecules (PRMs). These molecules, which include collectins, ficolins, and pentraxins, are specialised in the discrimination of self versus non-self and modified-self and share basic multifunctional properties including recognition and opsonisation of pathogens and apoptotic cells, activation and regulation of the complement cascade and tuning of inflammation. Neutrophils act as a reservoir of ready-made soluble PRMs, such as the long pentraxin PTX3, the peptidoglycan recognition protein PGRP-S, properdin and M-ficolin, which are stored in neutrophil granules and are involved in neutrophil effector functions. In addition, other soluble PRMs, such as members of the collectin family, are not expressed in neutrophils but can modulate neutrophil-dependent immune responses. Therefore, soluble PRMs are an essential part of the innate immune response and retain antibody-like effector functions. Here, we will review the expression and general function of soluble PRMs, focusing our attention on molecules involved in neutrophil effector functions.