Immobilized glycopolymers: Synthesis, methods and applications. (June 2016)

• Record Type: Journal Article
• Authors: von der Ehe, Christian; Weber, Christine; Gottschaldt, Michael; Schubert, Ulrich S.
• Is Part Of: Progress in polymer science. Volume 57(2016:Jun.)
• Page Start: 64
• Page End: 102
• Publication Date: 2016-06
• Subjects: AGET activator generated by electron transfer -- ATRP atom transfer radical polymerization -- ConA concanavalin A -- E. coli Escherichia coli -- ECL Erythrina cristagalli -- FRP free radical polymerization -- GAMA 2-gluconamidoethyl methacrylate -- GFP green fluorescence protein -- HDA hetero Diels Alder -- HEMA hydroxyethyl methacrylate -- HPA helix pomatia agglutinin -- LAMA lactobionamidoethyl methacrylate -- LCA Lens culinaris -- NHS N-hydroxysuccinimide -- PMMA poly(methyl methacrylate) -- PNA peanut agglutinin -- PPFS poly(pentafluorostyrene) -- PS poly(styrene) -- QCM quartz crystal microbalance -- RAFT reversible addition fragmentation chain transfer -- RCA Ricinus communis agglutinin -- SBA soy bean agglutinin -- SPR surface plasmon resonance -- WBA I winged bean agglutinin (Psophocarpus tetragonolobus) -- WGA wheat germ agglutinin; Glycopolymer -- Polymer immobilization -- Surface-initiated ATRP -- Controlled radical polymerization -- Surface functionalization; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2016.02.001
• Languages: English
• ISSNs: 0079-6700

Abstract

Abstract: Glycopolymers have been in the focus of intensive research due to their ability to mimic biological functions in recognition processes by interaction with carbohydrate binding proteins, so called lectins. For the same reason, the synthesis of glycosylated surfaces has evolved as a versatile route toward bioresponsive systems which can be used in protein chromatography. Also the detection of pathogens represents an application field of such glycosurfaces. The purpose of this review is to provide a summary of the different ways glycopolymers can be immobilized onto solid supports, thereby only covering the immobilization of synthetic glycopolymers. The emphasis was put on the chemical strategy for the immobilization step, although the synthesis of the glycopolymers is also explained, as well as selected analysis and application aspects of the resulting glycosylated surfaces.