The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs. (June 2016)

• Record Type: Journal Article
• Authors: Wang, Yen-Jen; Larsson, Mikael; Huang, Wei-Ting; Chiou, Shih-Hwa; Nicholls, Stephen J.; Chao, Jui-I; Liu, Dean-Mo
• Is Part Of: Progress in polymer science. Volume 57(2016:Jun.)
• Page Start: 153
• Page End: 178
• Publication Date: 2016-06
• Subjects: Cardiovascular diseases -- Drug delivery -- Nanoparticles -- Nanostructured -- Polymers -- Theranostic; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2016.01.002
• Languages: English
• ISSNs: 0079-6700

Abstract

Abstract: This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the possibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy.