A self-assembled lysinated perylene diimide film as a multifunctional material for neural interfacing. Issue 17 (18th April 2016)

• Record Type: Journal Article
• Authors: Bonetti, Simone; Prosa, Mario; Pistone, Assunta; Favaretto, Laura; Sagnella, Anna; Grisin, Ilja; Zambianchi, Massimo; Karges, Saskia; Lorenzoni, Andrea; Posati, Tamara; Zamboni, Roberto; Camaioni, Nadia; Mercuri, Francesco; Muccini, Michele; Melucci, Manuela; Benfenati, Valentina
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 17(2016)
• Page Start: 2921
• Page End: 2932
• Publication Date: 2016-04-18
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb02299a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : We report the design, synthesis and structure–property investigation as neural interface of a new perylene diimide material (PDI-Lys) bearing lysine end substituents. Abstract : We report the design, synthesis and structure–property investigation of a new perylene diimide material (PDI-Lys) bearing lysine end substituents. Water processed films of PDI-Lys were prepared and their self-assembly, morphology and electrical properties in both inert and air environments were theoretically and experimentally investigated. With the aim of evaluating the potential of PDI-Lys as a biocompatible and functional neural interface for organic bioelectronic applications, its electrochemical impedance as well as the adhesion and viability properties of primary neurons on the PDI-Lys films were studied. By combining theoretical calculations and electrical measurements we show that due to conversion between neutral and zwitterionic anions, the PDI-Lys film conductivity increased significantly upon passing from air to an inert atmosphere, reaching a maximum value of 6.3 S m −1 . We also show that the PDI-Lys film allows neural cell adhesion and neuron differentiation and decreases up to 5 times the electrode/solution impedance in comparison to a naked gold electrode. The present study introduces an innovative, water processable conductive film usable in organic electronics and as a putative neural interface.