Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases. Issue 15 (30th March 2016)

• Record Type: Journal Article
• Authors: Wei, Wei; Zhu, Dan; Wang, Zhenhua; Ni, Dezhi; Yue, Hua; Wang, Shuang; Tao, Yong; Ma, Guanghui
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 15(2016)
• Page Start: 2548
• Page End: 2552
• Publication Date: 2016-03-30
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb02568k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Positively charged armed nanoparticles can accumulate in the ocular fundus by utilizing the natural intraocular electrical field, and further penetrate into the fundus sub-layers by optimizing their charge density. Abstract : Recruiting positively charged armed nanoparticles into the ocular fundus was achieved by utilizing the natural intraocular electrical field. Their subsequent penetration into the fundus sub-layers was also tuned by optimizing the surface charge density. In addition to the sustained release behavior, such a precise delivery fulfilled various intraocular delivery requirements for different chorioretinal diseases.