Monocyte cell membrane-derived nanoghosts for targeted cancer therapy. Issue 13 (15th March 2016)

• Record Type: Journal Article
• Authors: Krishnamurthy, S.; Gnanasammandhan, M. K.; Xie, C.; Huang, K.; Cui, M. Y.; Chan, J. M.
• Is Part Of: Nanoscale. Volume 8:Issue 13(2016)
• Page Start: 6981
• Page End: 6985
• Publication Date: 2016-03-15
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr07588b
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Core–shell type 'nanoghosts' were synthesized with a biodegradable PLGA core and a monocyte cell membrane-derived shell. The ∼200 nm doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines. Abstract : Core–shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.