A Convenient Palladium‐Catalyzed Reductive Carbonylation of Aryl Iodides with Dual Role of Formic Acid. Issue 17 (2nd March 2016)

• Record Type: Journal Article
• Authors: Qi, Xinxin; Li, Chong‐Liang; Wu, Xiao‐Feng
• Is Part Of: Chemistry. Volume 22:Issue 17(2016)
• Page Start: 5835
• Page End: 5838
• Publication Date: 2016-03-02
• Subjects: aromatic aldehydes -- CO source -- formic acid -- palladium -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201600387
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Palladium‐catalyzed reductive carbonylation of aryl halides represents a straightforward pathway for the synthesis of aromatic aldehydes. The known reductive carbonylation procedures either require CO gas or complexed compounds as CO sources. In this communication, we developed a palladium‐catalyzed reductive carbonylation of aryl iodides with formic acid as the formyl source. As a convenient, practical, and environmental friendly methodology, no additional silane or H2 was required. A variety of aromatic aldehydes were isolated in moderate to excellent yields under mild reaction conditions. Notably, this is the first procedure on using formic acid as the formyl source. Abstract : Say no to CO gas ! A convenient, practical, and environmental friendly palladium‐catalyzed reductive carbonylation of aryl iodides with formic acid as the formyl source has been developed (see scheme). No additional silane or H2 was required here. A variety of aromatic aldehydes were isolated in moderate to excellent yields under mild reaction conditions.