Carboxylation of Phenols with CO2 at Atmospheric Pressure. Issue 20 (31st March 2016)

• Record Type: Journal Article
• Authors: Luo, Junfei; Preciado, Sara; Xie, Pan; Larrosa, Igor
• Is Part Of: Chemistry. Volume 22:Issue 20(2016)
• Page Start: 6798
• Page End: 6802
• Publication Date: 2016-03-31
• Subjects: carbon dioxide -- Kolbe–Schmitt reaction -- phenols -- salicylic acids -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201601114
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A convenient and efficient method for the ortho ‐carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe–Schmitt method, which requires very high pressures of CO2 . The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids. Abstract : 1 Atm CO2 ! First example of the Kolbe–Schmitt carboxylation able to proceed efficiently at atmospheric CO2 pressure for a variety of phenol substrates has been developed (see scheme). 2, 4, 6‐Trimethylphenol proved to be the key for this carboxylation, significantly increasing the initial reaction rate as well as improving the yield over the conventional process.