Antiobesity Effect of SA37 in High‐Fat Diet‐induced Obese C57BL/6J Mice. (12th April 2016)

• Record Type: Journal Article
• Authors: Kafle, Bhooshan; Khadka, Deegendra; Park, Byung Ho; Kim, Chan Kyung; Cho, Hyeongjin
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 37:Number 5(2016)
• Page Start: 621
• Page End: 625
• Publication Date: 2016-04-12
• Subjects: Antiobesity -- Mouse -- Protein tyrosine phosphatase 1B -- IκB kinase β; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.10730
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : SA37 inhibits protein tyrosine phosphatase 1B (PTP1B) with a medium potency, and inhibits IκB kinase β (IKKβ) at a submicromolar half‐maximal inhibitory concentration. In animal study, SA37 reduced diet‐induced weight gain in mice, without significantly ameliorating glucose tolerance and lipid parameters. These observations coincide partly with PTP1B knockout but are inconsistent with IKKβ depletion in mice. The effect ofSA37 on high‐fat diet (HFD)‐induced obese mice was compared with previous results obtained by the authors' group on a series ofSA compounds that exhibited different inhibitory potencies toward IKKβ and PTP1B. Abstract :