Tacky cyclic olefin copolymer: a biocompatible bonding technique for the fabrication of microfluidic channels in COC. Issue 9 (4th April 2016)

• Record Type: Journal Article
• Authors: Keller, Nico; Nargang, Tobias M.; Runck, Matthias; Kotz, Frederik; Striegel, Andreas; Sachsenheimer, Kai; Klemm, Denis; Länge, Kerstin; Worgull, Matthias; Richter, Christiane; Helmer, Dorothea; Rapp, Bastian E.
• Is Part Of: Lab on a chip. Volume 16:Issue 9(2016)
• Page Start: 1561
• Page End: 1564
• Publication Date: 2016-04-04
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c5lc01498k
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : A fast and cost-efficient process for bonding of COC for the fabrication of biologically functionalized microfluidic channels is presented. Abstract : Cyclic olefin copolymer (COC) is widely used in microfluidics due to its UV-transparency, its biocompatibility and high chemical resistance. Here we present a fast and cost-effective solvent bonding technique, which allows for the efficient bonding of protein-patterned COC structures. The bonding process is carried out at room temperature and takes less than three minutes. Enzyme activity is retained upon bonding and microstructure deformation does not occur.