Direct reductive amination of aldehydes with nitroarenes using bio-renewable formic acid as a hydrogen source. Issue 8 (6th January 2016)

• Record Type: Journal Article
• Authors: Zhang, Qi; Li, Shu-Shuang; Zhu, Ming-Ming; Liu, Yong-Mei; He, He-Yong; Cao, Yong
• Is Part Of: Green chemistry. Volume 18:Issue 8(2016)
• Page Start: 2507
• Page End: 2513
• Publication Date: 2016-01-06
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c5gc02583d
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Direct reductive amination of aldehydes with nitroarenes can be carried out efficiently in neat water in the presence of a single phase rutile titania supported gold catalyst using FA as the hydrogen donor. Abstract : Reductive amination (RA) is one of the most important transformations in organic chemistry. A versatile and sustainable gas-free RA of aldehydes carried out directly with cheaply available nitroarenes using stoichiometric amounts of non-toxic and entirely renewable formic acid (FA) as the terminal reductant is described herein. A single phase rutile titania supported gold (Au/TiO2 -R) catalyst is shown to catalyse efficiently this FA-based direct RA in neat water under mild reaction conditions. The broad scope, mild and neutral conditions, together with CO2 and water as environmental harmless byproducts, make this transformation very useful. Moreover, straightforward examples of the direct construction of bioactive heterocyclic compounds containing a benzimidazole motif were achieved through this protocol.