Scaling-down antibody radiolabeling reactions with zirconium-89. Issue 15 (17th March 2016)

• Record Type: Journal Article
• Authors: Knight, James C.; Paisey, Stephen J.; Dabkowski, Adam M.; Marculescu, Cristina; Williams, Anwen S.; Marshall, Christopher; Cornelissen, Bart
• Is Part Of: Dalton transactions. Volume 45:Issue 15(2016)
• Page Start: 6343
• Page End: 6347
• Publication Date: 2016-03-17
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c5dt04774a
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A 89 Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale has been reported. Abstract : The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable 89 Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.