Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells. Issue 2 (7th March 2016)

• Record Type: Journal Article
• Authors: Wongrakpanich, Amaraporn; Mudunkotuwa, Imali A.; Geary, Sean M.; Morris, Angie S.; Mapuskar, Kranti A.; Spitz, Douglas R.; Grassian, Vicki H.; Salem, Aliasger K.
• Is Part Of: Environmental science. Volume 3:Issue 2(2016)
• Page Start: 365
• Page End: 374
• Publication Date: 2016-03-07
• Subjects: Environmental sciences -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5en00271k
• Languages: English
• ISSNs: 2051-8153

Abstract

Abstract : The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. Abstract : The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu 2+ and causing a differential impact on cytotoxicity.