In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function. (May 2016)

• Record Type: Journal Article
• Authors: Lagarde, Michel; Calzada, Catherine; Guichardant, Michel; Véricel, Evelyne
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 108(2016:May)
• Page Start: 1
• Page End: 4
• Publication Date: 2016-05
• Subjects: Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2016.03.008
• Languages: English
• ISSNs: 0952-3278

Abstract

Abstract: Docosahexaenoic acid (DHA) is a prominent nutrient of marine lipids. Together with eicosapentaenoic acid, it is recognized as a protective molecule against atherosclerosis and thrombosis through the regulation of blood cell functions, especially platelets. Its high unsaturation index may however make it prone to peroxidation, which is usually considered as deleterious. This short review takes into consideration this possibility related to DHA concentrations both in vitro and in vivo . It is suggested that protective effects of DHA on platelet activation depend on the reduction of oxidative stress, and appear bimodal with the abolishment of such a protection when DHA is used at relatively high concentrations. Highlights: Docosahexaenoic acid exerts bimodal effects on blood platelet aggregation, oxidized-induced mononuclear cells apoptosis. Docosahexaenoic acid at low concentrations increases vitamin E whereas high concentrations tend to induce oxidative stress. Low doses of docosahexaenoic acid down regulate platelet activation and oxidative stress in diabetic and elderly subjects.