Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor. (June 2016)

• Record Type: Journal Article
• Authors: Singla, Navneet; Gupta, Kirti; Kapoor, Ankur
• Is Part Of: Journal of clinical neuroscience. Volume 28(2016:Jun.)
• Page Start: 182
• Page End: 184
• Publication Date: 2016-06
• Subjects: Cranial nerves -- Ganglioglioma -- Mixed glioneural tumor -- Olfactory sheath; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2015.11.022
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: We present a case of olfactory sheath ganglioglioma. These are uncommon mixed glioneural tumors, reported to affect variable sites in central nervous system. To date only the optic nerve and trigeminal nerve have been reported to be ganglioglioma sites amongst the cranial nerves. Abstract: Gangliogliomas are rare slow growing tumors with a mixed population of dysplastic ganglion cells and glial components, reported at variable sites within the central nervous system, including the frontal, parietal and occipital lobes, the striatum, cerebellum, pituitary and pineal glands as well as the spinal cord. Rarely gangliogliomas have been reported arising within the cranial nerves, including the optic and trigeminal nerve. We present the first patient, to our knowledge, where such a tumor originated from the olfactory sheath. Migration defects leading to entrapment of sensory neurons during development is believed to be responsible for the pathogenesis of these lesions. The extent of surgical extirpation and histopathological anaplasia are important prognosticators. While gangliogliomas are rare tumors, it is crucial to consider them in the differential diagnosis of non-enhancing, poorly localized lesions along the cranial nerves.