Bifunctional AgOAc/ThioClickFerrophos catalyzed asymmetric 1, 3-dipolar cycloaddition reaction of azomethine ylides to nitroalkenes. Issue 21 (26th May 2016) - Kimura, Midori
Abstract: AgOAc/ThioClickFerrophos (TCF) complex catalyzed the 1, 3-dipolar cycloaddition of azomethine ylides (glycine imino ester) to nitroalkenes. The corresponding endo -cycloadducts (88:12–98:2 endo / exo ) were afforded in good yields with high enantioselectivities, up to 98% ee, without addition of external amine. AgOAc/TCF works as a bifunctional (Lewis acid and base) catalyst. Graphical abstract: