Monocyte and macrophage contributions to cardiac remodeling. (April 2016)

• Record Type: Journal Article
• Authors: Hulsmans, Maarten; Sam, Flora; Nahrendorf, Matthias
• Is Part Of: Journal of molecular and cellular cardiology. Volume 93(2016:Apr.)
• Page Start: 149
• Page End: 155
• Publication Date: 2016-04
• Subjects: ACE angiotensin-converting enzyme -- CCR2 chemokine (C–C motif) receptor-2 -- CX3CR1 chemokine (C–X3–C motif) receptor-1 -- DOCA deoxycorticosterone acetate -- HIF hypoxia-inducible factor -- HSCs hematopoietic stem cells -- IL interleukin -- IRF5 interferon regulatory factor-5 -- MCP-1 monocyte-chemoattractant protein-1 -- MI myocardial infarction -- miR microRNA -- MMPs matrix metalloproteinases -- PDGF platelet-derived growth factor -- TGFβ transforming growth factor-β -- TIMPs tissue inhibitors of MMPs -- TNFα tumor necrosis factor-α; Monocytes -- Macrophages -- Myocardial infarction -- Hemodynamic stress -- Fibrosis -- Cardiac remodeling; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2015.11.015
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: The mammalian heart contains a population of resident macrophages that expands in response to myocardial infarction and hemodynamic stress. This expansion occurs likely through both local macrophage proliferation and monocyte recruitment. Given the role of macrophages in tissue remodeling, their contribution to adaptive processes in the heart is conceivable but currently poorly understood. In this review, we discuss monocyte and macrophage heterogeneity associated with cardiac stress, the cell's potential contribution to the pathogenesis of cardiac fibrosis, and describe different tools to study and characterize these innate immune cells. Finally, we highlight their potential role as therapeutic targets. Highlights: Macrophages are an intrinsic part of the heart under physiological conditions. Cardiac macrophages expand in response to stress. Macrophage expansion through monocyte recruitment associates with cardiac remodeling Monocytes and macrophages may exert a wide range of pro- and anti-fibrotic actions.