Bis-phenanthridinium–adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures. Issue 3 (2nd April 2016)

• Record Type: Journal Article
• Authors: Tumir, Lidija-Marija; Šupljika, Filip; Piantanida, Ivo
• Is Part Of: Supramolecular chemistry. Volume 28:Issue 3/4(2016)
• Page Start: 267
• Page End: 274
• Publication Date: 2016-04-02
• Subjects: DNA recognition -- Phenanthridine–adenine conjugates -- fluorimetric titration -- CD titration; Macromolecules -- Periodicals; Supramolecular chemistry -- Periodicals; 547.005
• DOI: 10.1080/10610278.2015.1099655
• Languages: English
• ISSNs: 1061-0278

Abstract

Abstract: Two structurally similar bis-phenanthridinium–adenine conjugates (equipped with one or two adenines, respectively), exhibiting strong ds-DNA/RNA groove binding, revealed ratiometric fluorescent recognition of alternating AT-DNA with respect to other ds-DNA/RNA and ss-RNA. Further, CD spectra pattern of adenine–bis-phenanthridinium conjugate/polynucleotide complexes strongly depended on polynucleotide secondary structure. Attached adenine was essential for spectrophotometric recognition response, ds-DNA stabilisation and orientation of compounds regarding chiral DNA helix. Abstract :