Copper(II)‐Mediated Synthesis of Indolequinones from Bromoquinones and Enamines. Issue 11 (20th February 2013)

• Record Type: Journal Article
• Authors: Inman, Martyn; Moody, Christopher J.
• Is Part Of: European journal of organic chemistry. Issue 11(2013)
• Page Start: 2179
• Page End: 2187
• Publication Date: 2013-02-20
• Subjects: Synthetic methods -- Cycliza­tion -- Nitrogen heterocycles -- Quinones -- Copper; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201201597
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: The reaction of enamines and bromoquinones in the presence of copper(II) acetate and potassium carbonate results in a regiospecific synthesis of indolequinones. The reaction is broad in scope and scalable and provides a route to the core structure that is present in several biologically interesting natural and synthetic compounds. Abstract : The reaction of readily available enamines and bromoquinones in the presence of copper(II) acetate and potassium carbonate afford indolequinones. This reaction is regiospecific, scalable, and versatile and provides a route to the quinone core that is present in biologically interesting natural and synthetic compounds.