The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity. (14th June 2016)

• Record Type: Journal Article
• Authors: Dyer, Adam H.; Vahdatpour, Cyrus; Sanfeliu, Albert; Tropea, Daniela
• Is Part Of: Neuroscience. Volume 325(2016)
• Page Start: 89
• Page End: 99
• Publication Date: 2016-06-14
• Subjects: AMPA a-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid -- ADP Activity-Dependent Plasticity -- BDNF Brain Derived Neurotrophic Factor -- CNS Central Nervous System -- EE Environmental Enrichment -- EPSP Excitatory Post-Synaptic Potential -- GluR1 glutamate receptor 1 -- GSK3β glycogen synthase kinase 3β -- IGF1R IGF-1 Receptor -- IGF-1 Insulin-Like Growth Factor 1 -- IGFBPs Insulin-Like Growth Factor-Binding Proteins -- LTD Long-Term Depression -- LTP Long-Term Potentiation -- MD Monocular Deprivation -- NMDA N-methyl-d-aspartate -- PSD-95 Post-Synaptic Density Protein 95 -- TBI Traumatic Brain Injury; IGF-1 -- development -- plasticity -- CNS; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.03.056
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Highlights: Insulin-Like Growth Factor 1 controls brain development and plasticity. Insulin-Like Growth Factor 1 modulates different systems including neuronal transmission, metabolism and morphology. Insulin-Like Growth Factor 1 is a neuroprotective and regenerative factor in post-traumatic injury. Abstract: Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has been shown to have potent effects on cellular neuroplasticity. Neuroplasticty refers to the adaptive changes made by the CNS in the face of changing functional demands and is crucial in processes such as learning and memory. IGF-1, signaling through its glycoprotein receptor (IGF-1R), and canonical signaling pathways such as the PI3K-Akt and Ras-Raf-MAP pathways, has potent effects on cellular neuroplasticity in the CNS. In the present review, the role of IGF-1 in brain development is reviewed, followed by a detailed discussion of the role played by IGF in cellular neuroplasticity in the CNS. Findings from models of perturbed and reparative plasticity detailing the role played by IGF-1 are discussed, followed by the electrophysiological, structural and functional evidence supporting this role. Finally, the post-lesion and post-injury roles played by IGF-1 are briefly evaluated. We discuss the putative neurobiology underlying these changes, reviewing recent evidence and highlighting areas for further research.