Altered striatal intrinsic functional connectivity in pediatric anxiety. (May 2016)

• Record Type: Journal Article
• Authors: Dorfman, Julia; Benson, Brenda; Farber, Madeline; Pine, Daniel; Ernst, Monique
• Is Part Of: Neuropsychologia. Volume 85(2016)
• Page Start: 159
• Page End: 168
• Publication Date: 2016-05
• Subjects: Anxiety -- Adolescence -- Neuroimaging -- Resting state fMRI -- Reward -- Striatum; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2016.03.019
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: Anxiety disorders are among the most common psychiatric disorders of adolescence. Behavioral and task-based imaging studies implicate altered reward system function, including striatal dysfunction, in adolescent anxiety. However, no study has yet examined alterations of the striatal intrinsic functional connectivity in adolescent anxiety disorders. The current study examines striatal intrinsic functional connectivity (iFC), using six bilateral striatal seeds, among 35 adolescents with anxiety disorders and 36 healthy comparisons. Anxiety is associated with abnormally low iFC within the striatum (e.g., between nucleus accumbens and caudate nucleus), and between the striatum and prefrontal regions, including subgenual anterior cingulate cortex, posterior insula and supplementary motor area. The current findings extend prior behavioral and task-based imaging research, and provide novel data implicating decreased striatal iFC in adolescent anxiety. Alterations of striatal neurocircuitry identified in this study may contribute to the perturbations in the processing of motivational, emotional, interoceptive, and motor information seen in pediatric anxiety disorders. This pattern of the striatal iFC perturbations can guide future research on specific mechanisms underlying anxiety. Highlights: Anxiety disorders have been associated with striatal dysfunction. Resting state fMRI was used to investigate striatal connectivity in a large sample of adolescents with anxiety disorders. Anxiety was found to be associated with lower connectivity within the striatum and between striatum and prefrontal regions. This finding differs from adult anxiety, suggesting interaction of developmental stage and anxiety on striatal connectivity.