Blood free fatty acids were not increased in high-fat diet induced obese insulin-resistant animals. Issue 2 (March 2016)

• Record Type: Journal Article
• Authors: Jiang, Junfeng; Wu, Yongjie; Wang, Xiaoxia; Lu, Li; Wang, Li; Zhang, Baolai; Cui, Mingxia
• Is Part Of: Obesity research & clinical practice. Volume 10:Issue 2(2016:Mar./Apr.)
• Page Start: 207
• Page End: 210
• Publication Date: 2016-03
• Subjects: Insulin resistance -- Free fatty acids -- Obesity -- Ciliary neurotrophic factor -- Sibutramine; Obesity -- Research -- Periodicals; Obesity -- Treatment -- Periodicals; Obesity -- Periodicals; Obésité -- Recherche -- Périodiques; Obésité -- Traitement -- Périodiques; Obesity -- Research; Obesity -- Treatment; Electronic journals; Periodicals; 616.398
• DOI: 10.1016/j.orcp.2015.06.005
• Languages: English
• ISSNs: 1871-403X

Abstract

Summary: Objective: The close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals. Methods: Obese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs. Results: The serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment. Conclusion: The results suggest that blood FFA are unlikely the link between obesity and insulin resistance.